How to Use SereneSix
Calm When it Matters
Designed for Real Life
Science in a Sleek Band
Australian Owned
The Technology Behind the Calm
NervSync™ Rhythmic System
PC6 Acupoint Positioning
One-Touch Activation
Skin-Safe Comfort Vibration
Calm, Without Complication
Typical Stress-Relief Devices
Calm, Without Complication
Typical Stress-Relief Devices
How SereneSix
Works with your Body
Switches On Calm
Shifts You Out of Stress Mode
Practical Outcomes You Can Feel
The Science Behind PC6
PC6 Acupressure Point
PC6: The Most Researched Acupressure Point
The Pericardium 6 (PC6) point on the inner wrist has been studied in over 43 randomised clinical trials. It is the only acupressure point documented in multiple systematic reviews as producing measurable results when applied on its own — without combining with other points.
Every acupressure study reviewed reported a positive, measurable result.
Lee & Frazier (2011), Journal of Pain and Symptom Management, 42(4). | Au et al. (2015), Acupuncture in Medicine, 33(5).
43
RCTs reviewed across all acupressure symptom categories
100%
Of acupressure studies reviewed reported a positive result
Every acupressure study reviewed reported a positive, measurable result.
Randomised Controlled Trial — 108 Participants
Acupressure Supported Stress Relief in a Clinical Trial
Results were measured using a recognised, validated clinical scale.
Hmwe et al. (2015), International Journal of Nursing Studies, 52(2), 509–518. RCT, n=108.
✓ 108 Participants
✓ 4-Week RCT
✓ Peer-Reviewed
In a randomised controlled trial of 108 participants, acupressure delivered three times a week over four weeks significantly eased stress and tension, and lifted overall mood, compared to a control group.Results were measured using a recognised, validated clinical scale.
Neurological & Brain Research
PC6 Stimulation Shows Measurable Effects in Brain Research
Separately, rhythmic peripheral vibration has been shown to increase connectivity across limbic brain structures involved in mood and focus, and to activate the brain's attention and alertness system, supporting sharper focus.
Li et al. (2022), Neuropsychiatric Disease and Treatment, 18, 1375–1384. Randomised single-blind study, n=24. | Donovan et al. (2025), PLOS ONE / PMC. | Tan et al. (2024), Brain Stimulation, 17(2).
✓ Brain Scan Verified
Focus & alertness
In a randomised study, PC6 stimulation produced measurable changes in brain activity — confirmed by functional MRI (fMRI) scanning — real, visible proof that PC6 stimulation reaches the brain.Separately, rhythmic peripheral vibration has been shown to increase connectivity across limbic brain structures involved in mood and focus, and to activate the brain's attention and alertness system, supporting sharper focus.
8-Week Double-Blind Clinical Trial
Wrist-Worn Rhythmic Vibration: Real-World Trial
The result: participants felt calmer and more focused — and researchers confirmed that simple, consistent rhythmic stimulation at the wrist was itself the active ingredient. No app, no calibration needed — exactly how SereneSix is built.
Bartlett et al. (2024), PLOS Digital Health, 3(7), e0000555. London South Bank University / European Regional Development Fund.
Calm
Focus
A double-blind randomised controlled trial published in PLOS Digital Health put wrist-worn rhythmic vibration to the test over 8 weeks.The result: participants felt calmer and more focused — and researchers confirmed that simple, consistent rhythmic stimulation at the wrist was itself the active ingredient. No app, no calibration needed — exactly how SereneSix is built.
Finding the PC6 Point
Two Built-In Modes
Your Calm Grows Over Time